Commentary: the c9orf72 repeat expansion disrupts nucleocytoplasmic transport
Zhang et al.have recently investigated the complex mechanisms that lead to impairment of the normal trafficking through the nuclear pore complex associated with G 4 C 2 HRE. The authors also studied the RanGAP/G 4 C 2 RNA interaction in induced pluripotent stem cell neurons, derived from multiple C9orf72 ALS patients and noted that RanGAP →